Christina Applegate, who has been experiencing a number of sclerosis (MS) signs for a while, just lately opened up in regards to the bodily modifications introduced on by the progressive immune dysfunction.

During an episode of the ?MeSsy? podcast on Tuesday, August 20, which she co-hosts with actor Jamie-Lynn Sigler, Applegate used a selected youngsters?s guide character to explain how her physique has modified.

?I have no muscles in my legs, which I showed you,? Applegate, 52, informed Sigler. ?I look like Humpty Dumpty. My little tiny, weird legs and then my big menopausal belly.?

Sigler, 43, who was identified with MS in 2001 on the age of 20, shared that the dysfunction has pressured her to change into a ?homebody,? a major shift from her as soon as energetic and athletic life-style.

?I was the most active, athletic ? if everyone was going to go play a sport, I was in it till the end,? Sigler recalled. ?If everyone was going to go for a walk, I was the first one to be out in the street. That was me, that was my personality. That was my life. I just always wanted to be doing something, and up and out, I was never home. Now I feel like I?m always home.?

Applegate, in distinction, admitted that she has at all times been extra of a homebody, preferring the consolation of her mattress. However, the development of MS has made her much more reliant on staying in.

?I like being home now because, well, I like being in my bed, but also I don?t want to be in my bed,? she stated. ?But once I do go out, I?m happy I?ve done it.?

Applegate defined that her buddies now perceive her limitations and don?t count on bodily demanding actions, similar to mountain climbing. ?That?s not going to happen because I?m so not conditioned right now,? she stated, including that the shortage of bodily exercise has left her feeling deconditioned, making even small exertions like strolling uphill really feel overwhelming.

In line with the title of their podcast episode, ?I Love When People Cancel,? Applegate talked about that she asks her buddies for ?grace? in case she must ?cancel right before? plans to hang around.

MS is a illness through which the physique?s immune system assaults the mind and spinal twine, resulting in signs similar to muscle stiffness and difficulties with strolling and speaking.

The Anchorman, Married With Children, and Bad Moms star beforehand mentioned her insecurities about getting older and her look throughout an August 1 episode of the podcast.